| Player | Pos. | Ht. | Wt. | Grad. | Commit Status |
|---|---|---|---|---|---|
| Tom Sims Kansas City Chiefs | DT | 6'2 | 291 | 1985 | Western Michigan (MI) |
| Charlie Sims Jr. Cass Tech Technicians | OT, DT | 2021 | 13 Offers | ||
| Julius Sims Jr. Muskegon Big Reds / Bowling Green Falcons | S, WR | 6'2 | 185 | 2021 | Bowling Green State (OH) |
| Brendan Sine Charlotte Orioles | K, P, RB, MLB | 5'11" | 190 | 2019 | 1 Offers |
| Eknoor Singh Grand Blanc Bobcats | OT, OG | 6'3 | 275 | 2019 | Undecided |
| Jason Singleton Mumford Mustangs | WR | 6'2 | 205 | 2019 | Undecided |
| Luke Sinkevics Walled Lake Western Warriors | WR, S | 5'10" | 150 | 2020 | Undecided |
| Bennett Sinner Wyoming Tri-Unity Christian Defenders | WR, OLB | 6' | 2019 | Undecided | |
| Joshua Sisk Vandercook Lake Jayhawks | QB | 5'10" | 160 | 2019 | Undecided |
| Grant Sitterly Saline Hornets | 2019 | Undecided | |||
| Calvin Sitto Sterling Heights Stevenson Titans | OLB | 2018 | Undecided | ||
| Nate Siwajek Dakota Cougars | WR, TE, QB | 6’6 | 180 | 2019 | Undecided |
| Nathan Siwajek Dakota Cougars | WR, TE | 6’6 | 180 | 2019 | Undecided |
| Gabe Skaer Orchard Lake Saint Mary's Eaglets | MLB | 6'3" | 190 | 2019 | Undecided |
| Bobby Skinner Montrose Rams | QB | 2021 | Undecided | ||
| Caden Skinner Midland Dow Chargers | QB | 62" | 185 | 2018 | Undecided |
| Harold Skinner Clarkston Wolves | S | 6’1 | 185 | 2021 | Undecided |
| Harold Skinner II Clarkston Wolves | WR | 6'1 | 160 | 2021 | Undecided |
| Leo Skupin White Lake Lakeland Eagles | RB, K | 5'10 | 150 | 2020 | Saginaw Valley State (MI) |
| Johnathan Slack Jr Detroit King Crusaders | OT | 6’2 | 240 | 2023 | 6 Offers |
| Sawyer Slanec Chippewa Valley Big Reds | DE, TE | 6'2 | 220 | 2020 | Undecided |
| Jawon slater Ortonville Brandon Blackhawks | RB, S | 6'0 | 185 | 2021 | Undecided |
| Jawon slater Ortonville Brandon Blackhawks | RB | 6'0 | 185 | 2021 | Undecided |
| Jawon slater Ortonville Brandon Blackhawks | RB | 6'0 | 185 | 2021 | Undecided |
| Jawon slater Ortonville Brandon Blackhawks | RB, S | 6'0 | 185 | 2021 | Undecided |
| Jakob Slater Otsego Bulldogs | DT | 6'2 | 276 | 2020 | Madonna University (MI) |
| Jawon Slater Ortonville Brandon Blackhawks | RB, S | 5’11 | 180 | 2021 | Undecided |
| Devin Slaughter Riverview Gabriel Richard Pioneers | DE, OLB | 2018 | Undecided | ||
| Devin Slaughter Lincoln Park Railsplitters | DT, OG | 5’10 | 220 | 2021 | Undecided |
| Devin Slaughter Lincoln Park Railsplitters | OC, DT | 5’10 | 240 | 2021 | Undecided |
