Michigan Metro Athletic Conference - Blue
| Team | W - L (Conf.) | PF / PA (Conf.) | Streak (Conf.) | W - L (Total) | PF / PA (Total) | Streak (Total) |
|---|---|---|---|---|---|---|
| 14River Rouge Panthers | 0 - 0 | 0 / 0 | 0 | 6 - 2 | 320 / 109 | 3 |
| Voyageur Cougars | 0 - 0 | 0 / 0 | 0 | 2 - 5 | 194 / 170 | 1 |
* Signifies that game is non-conference
| August 26, 2021 - Thursday | Time | Score | |
|---|---|---|---|
| * | Voyageur Cougars Center Line Panthers | 7:00 PM | 12 - 13 |
| August 28, 2021 - Saturday | Time | Score | |
| * | Eastpointe Shamrocks 14River Rouge Panthers | 1:00 PM | 0 - 56 |
| September 3, 2021 - Friday | Time | Score | |
| * | 14River Rouge Panthers 6De La Salle Pilots | 7:00 PM | 29 - 38 |
| * | Voyageur Cougars Michigan Collegiate Cougars | 7:00 PM | 6 - 48 |
| September 10, 2021 - Friday | Time | Score | |
| * | 14River Rouge Panthers Battle Creek Lakeview Spartans | 7:00 PM | 50 - 0 |
| September 11, 2021 - Saturday | Time | Score | |
| * | Voyageur Cougars Detroit Community Hurricanes | 1:00 PM | 24 - 28 |
| September 17, 2021 - Friday | Time | Score | |
| * | Hamtramck Cosmos 14River Rouge Panthers | 7:00 PM | 0 - 1 |
| * | Southfield Bradford Bulldogs Voyageur Cougars | 7:00 PM | - |
| September 18, 2021 - Saturday | Time | Score | |
| * | Southfield Bradford Bulldogs Voyageur Cougars | 1:00 PM | - |
| September 24, 2021 - Friday | Time | Score | |
| * | Voyageur Cougars Melvindale ABT Gators | 4:00 PM | 62 - 6 |
| September 25, 2021 - Saturday | Time | Score | |
| * | 14River Rouge Panthers Saint Ignatius (OH) | 7:00 PM | 12 - 24 |
| October 1, 2021 - Friday | Time | Score | |
| * | 14River Rouge Panthers Portage Northern Huskies | 7:00 PM | 56 - 3 |
| October 2, 2021 - Saturday | Time | Score | |
| * | Detroit Leadership Cougars Voyageur Cougars | 1:00 PM | 32 - 24 |
| October 8, 2021 - Friday | Time | Score | |
| * | Detroit University Prep Panthers 14River Rouge Panthers | 7:00 PM | 0 - 71 |
| * | Voyageur Cougars Summit Academy Dragons | 7:00 PM | 14 - 20 |
| October 22, 2021 - Friday | Time | Score | |
| * | Southfield A&T Warriors 14River Rouge Panthers | 7:00 PM | 44 - 45 |
| October 23, 2021 - Saturday | Time | Score | |
| * | Allen Park Cabrini Monarchs Voyageur Cougars | Noon | 23 - 52 |
| October 29, 2021 - Friday | Time | Score | |
| * | 14River Rouge Panthers 29Harper Woods Pioneers | 7:00 PM | - |